Scientists Find Strong
Bacterial Glue
April 19, 2006 — By Associated Press
BLOOMINGTON, Ind. — A common bacteria
that clings to the inside of water pipes stays in place with the
strongest glue known to exist in nature, according to a team of
scientists that includes an Indiana University biologist.
The researchers found that the bacteria Caulobacter crescentus can
withstand a force equivalent to five tons per square inch -- the
pressure exerted by three or four cars balanced atop a quarter -- before
it is swept from its moorings.
Yves Brun, the IU biologist who co-authored the research, said the super
adhesive the bacteria produces could theoretically be mass produced for
engineering and medical purposes, including as a biodegradable glue to
replace sutures and staples in surgery.
"The challenge will be to produce large quantities of this glue without
it sticking to everything that is used to produce it," he told The
Herald-Times for a Tuesday story.
The findings appear in the April 11 issue of the Proceedings of the
National Academy of Science. Brun co-authored the research with Jay
Tang, a former IU physicist who now works at Brown University.
Brun has been working with C. crescentus -- a harmless and widely
studied bacterium that lives in rivers, streams and water pipes -- since
1990 as part of his work to understand genetic processes involved in
producing cells.
In their work, the team discovered that C. crescentus attaches itself to
surfaces with a long, slender stalk tipped with chains of sugar
molecules that are the source of its tenacity.
That substance is the strongest glue known to occur in nature and is
three times as strong as commercial "super" glue products, Brun said.
Because it works under water, even in salty water, he said that suggests
it could be used as a surgical adhesive, in joint replacement surgery
and in dental procedures.
But figuring out how to do it will require solving scientific and
engineering problems of surface chemistry and manufacturing processes.
IU engineer L. Ben Freund wrote the model used to analyze the bacteria's
adhesive abilities. Peter Tsang and Guanglai Li of Brown University
performed experiments and analyzed data.
Funding came from the National Science Foundation and the National
Institutes of Health.
Source: Associated Press
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