Hard Exercise Can Prevent Cell Death

Every day our bodies are dying, or rather, our millions of cells are dying. Fortunately they do not all die at once, and there is always another cell to take its place. What if people could stop their cells from dying? Wouldn't that be the same as eternal life? Well that is not possible, so the best people can do is delay the cellular inevitable. To do so merely entails exercise, an activity that people should be doing anyway. An Italian team of scientists at the University of Rome put their collective skills together to prove this hypothesis.

Apoptosis, the natural 'programmed' death of cells, is arrested in the aftermath of strenuous exercise. Researchers writing in the open access journal BMC Physiology studied peripheral blood mononuclear cells (PBMCs), isolated from whole blood samples taken from people after finishing a marathon, finding that the balance between expression of pro- and anti-apoptotic genes is shifted after the race.

Gabriella Marfe from the University of Rome 'Tor Vergata' led a team of researchers who studied ten amateur athletes after a 42km run. Marfe said, "Apoptosis is a normal physiological function dependent on a variety of signals, many of which can be modulated by strenuous exercise. Here, we've shown for the first time that exercise modulates expression of the sirtuin family of proteins, which may be key regulators of training".

The researchers believe that the sirtuin family of proteins, particularly SIRT1, may be involved in the protective effects of exercise against cell death. Speaking about these results, Marfe added, "Sirtuins may play a crucial role of mediators/effectors in the maintenance of skeletal and cardiac muscle tissues as well as neurons, thus explaining the synergic protective effects of physical exercise and calorie restriction for survival and ageing".

The authors also caution that any exercise people carry out should be done properly. Marfe said, "Untrained amateur athletes often do hard training without professional advice. Such intense and exhaustive exercise can be harmful to health. In order to achieve beneficial effects, we recommend that exercise training should form part of a lifelong regime with expert medical advice and supervision".

So everybody with a good set of knees should go out running today. It can help lose weight, stay in shape, and lose stress. Your cells will thank you.

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