The pseudoceratinapurpurea sea sponge has a
naturally-occurring chemical that blocks components involved in
cancer cell division and growth (Image: Dr Matt Fuchter)
Psammaplin A is a naturally occurring chemical found in the
sea sponge that has been found to block several components that
are involved in the growth and division of cancer cells. Dr
Matthew Fucher and his team at
Imperial
College London have developed a new, and inexpensive way of
manufacturing psammaplin A, and is using synthetic variations of
the chemical to better understand its anti-cancer properties,
which will help them in future efforts to create anti-cancer
drugs.
Biological studies revealed compounds from the synthetic
psammaplin A block the enzyme "histone deacetylase 1" (HDAC1,
class I). with preliminary results showing that the synthetic
variants are actually more potent than those occurring in
nature.
"New chemical routes towards the natural product psammaplin A
were developed with the particular view to preparing diverse
variants for biological assessment. These routes utilize cheap
and commercially available starting materials, and allowed
access to psammaplin A variants not accessible via currently
reported methods," says Dr Fuchter.
Deep sea organisms are commonly used in research into many
diseases, including malaria and cancer. The researchers say that
knowledge gained from these experiments will assist subsequent
drug design efforts, and has the potential to inspire new
anti-cancer drugs.
"Several highly effective cancer drugs were first discovered
as natural compounds. However, wonderful as Nature is, she is
only half-way there when it comes to beating cancer. Often
scientists can improve upon Nature's handiwork, by tweaking the
chemical structure of these molecules – just as Dr Fuchter has
discovered with psammaplin A," said Dr Mark Matfield, AICR's
scientific coordinator.
Dr Fuchter was awarded GBP106,079 (approx. US$170,570) from
the
Association for International Cancer Research (AICR), and he
is the youngest recipient so far. His paper was published online
recently in the Journal
Organic and Biomolecular Chemistry and is available
in print this month (February, 2011).
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