Breakthrough in the Fight Against Flu: Scientists Move Closer to
Universal Vaccine
October 08, 2013
Story at-a-glance
During the 2009 H1N1 pandemic, those who had more virus-killing
immune cells, known as CD8 T cells, either did not get sick or
had only mild flu symptoms
Researchers believe that getting a vaccine that prompts your
body to produce more CD8 T cells may protect you from getting
infected with the flu, or at least from having severe symptoms,
resulting in a ‘universal’ flu vaccine
Vitamin D has a direct immune-modulating effect on CD8 T cells
and vitamin-D deficiency may worsen CD8 T-cell deficiency
It may be, then, that the best ‘universal flu vaccine’ there is
doesn’t need to be ‘developed’ or ‘created’ – it already exists
in the form of natural vitamin D
By Dr. Mercola
Flu shots work, or more aptly often don’t work,
because they protect against just three or four strains of the
influenza virus – those strains of type A or type B influenza
that are suspected to be the most commonly circulating in any
given year.
The three or four influenza strains contained in annual flu
shots represent only a fraction of the 200 or so different
viruses known to circulate and cause flu-like symptoms each
year. In addition, only about 20 percent of suspected influenza
cases that occur during the flu season test positive for type A
or type B influenza.
So if the influenza strains contained in the flu shot aren’t a
good match for the strains circulating in any given year, it’s
obviously not going to do you much good. Even the US Centers for
Disease Control and Prevention (CDC) states:1
“During years when the flu vaccine is not well
matched to circulating viruses, it’s possible that no
benefit from flu vaccination may be observed.”
Researchers are unsurprisingly scrambling to be the first to
develop a universal flu
vaccine, one that would protect against all forms of
influenza. A team working for pharmaceutical company Sanofi
believes they may have discovered the secret, which, ironically,
produces an effect similar to that of
vitamin D.
A Universal Flu Vaccine That Boosts Your Immune System?
Currently, flu vaccines work by introducing a live or
inactivated form of flu virus into your body, prompting your
immune system to produce antibodies that may help prevent
infection against wild-type circulating influenza viruses you
are exposed to in your environment. It’s worth noting that even
when the flu vaccine is well matched, it still has
extremely unimpressive rates of effectiveness.
During the 2012-2013 flu season, for instance, US flu
vaccines were only
nine percent effective against type A (H3N2) influenza
strain in people 65 and older. Across all age groups reviewed by
the CDC, the flu vaccine's effectiveness was found to be just 56
percent—in essence, the statistical equivalent of a coin toss.
Researchers working on the universal flu vaccine realized
that during the 2009 H1N1 pandemic, those who had more
virus-killing immune cells, known as CD8 T cells, did not get
sick or had only mild flu symptoms.
Thanks to this ‘natural experiment,’ the researchers
suggested that getting your body to produce more CD8 T cells may
protect you from getting infected with the flu, or at least from
having severe symptoms.2“This provides the blueprint for developing a universal flu
vaccine,” the study’s lead researcher said.3
Vitamin D Deficiency Is Already Linked to Low CD8 T Cells
The drug company researchers brag that they already know how
to use a vaccine to stimulate the immune system to produce more
CD8 T cells. However, they do not mention that CD8 T cell
deficiency is already a known feature of many chronic autoimmune
diseases, including multiple sclerosis (MS), rheumatoid
arthritis, ulcerative colitis and more, and is also found in
relatives of people with autoimmune diseases.
Interestingly, researchers have revealed that vitamin D has a
direct immune-modulating effect on CD8 T cells in people with
early multiple sclerosis and in healthy control
subjects.4
It has also been proposed that deprivation of sunlight and
vitamin D at higher latitudes facilitates the development of
autoimmune diseases by aggravating the CD8 T-cell deficiency.5
It may be, then, that the best ‘universal flu vaccine’ there is
doesn’t need to be ‘developed’ or ‘created’ – it already exists
in the form of vitamin D.
Vitamin D Is Essential for Flu Prevention
Vitamin D is a typically overlooked and highly effective
antimicrobial agent, producing 200 to 300 different
antimicrobial peptides in your body that kill bacteria, viruses
and fungi. So optimizing your levels will not only help send the
flu virus packing, it can help prevent you from getting sick in
the first place.
In contrast to what is known about flu vaccines, this
recommendation has been steadily gaining scientific validation.
In fact, there’s compelling evidence suggesting influenza, colds
and flu-like illnesses may actually be symptoms of
vitamin D deficiency.
Dr. John Cannell, founder of the Vitamin D Council, was one
of the first to introduce the idea that vitamin D deficiency may
actually be an underlyingcause of influenza,
which would help explain its apparent benefits as a flu-fighter.
His hypothesis was published in the journal Epidemiology and
Infection in 2006,6
which was followed up with another study published in the
Virology Journal in 2008.7
His hypothesis received further support and confirmation when,
in the following year, the largest and most nationally
representative study of its kind to date discovered that people
with the lowest blood vitamin D levels reported having
significantly more recent colds or cases of the flu.8
In another study, published in 2010,9
researchers investigated the effect of vitamin D on the
incidence of seasonal influenza A in schoolchildren. Over the
course of a year, influenza A occurred in just 10.8 percent of
the children in the vitamin D group, compared with 18.6 percent
of the children in the placebo group. According to the authors:
"This study suggests that vitamin D3 supplementation
during the winter may reduce the incidence of influenza A,
especially in specific subgroups of schoolchildren."
How to Get Your Vitamin D Levels Optimized for Flu Season
Research on vitamin D is moving forward swiftly, so you’d be
well advised to stay on
top of the latest developments as recommendations are
refined and updated. I will cover the latest developments here,
so you may want to share this article with your peers.
First, it’s important to remember that sun exposure is the best
way to optimize your vitamin D levels as your body has built-in
“fail-safe” mechanisms that prevent detrimental side effects
from occurring. Last year, I created a
video to help you determine if you can get enough vitamin D
from sun exposure in your area at different times of the year.
Based on additional information received, I now believe that
my previous position was too strict... The good news is you can
likely get vitamin D under far less ideal conditions than
previously suggested.
The radiation from the sun that reaches the Earth's surface
(and hence your body) is partially filtered out by the
atmosphere. I had previously stated that UVB rays will only
penetrate the atmosphere when the sun is above an angle of
about 50° from the horizon, and that when the sun is lower
than 50°, the ozone layer will absorb vitamin D-producing
UVB-rays while allowing the longer, and more harmful, UVA-rays
to get through, which would defeat the purpose of spending time
in the sun.
This recommendation is likely too rigid. According to experts
in the field, you can likely get sufficient amounts of UVB
radiation when the sun is as low as 30 degrees above the
horizon, or whenever the temperature is warm enough
to expose large amounts of skin.
I thank John Hochman, MSME, for bringing this to my
attention. According to Dr. Ola Engelsen with the Norwegian
Institute for Air Research, the creator of a calculator10
that takes a number of factors into consideration to give you an
estimate of how many minutes of exposure you need to produce the
equivalent of 1,000 IUs of vitamin D, the sun must be more than
15 degrees above the horizon during cloudless conditions.
If you decide to take supplements to boost your vitamin D
levels, based on the latest investigations by Carole Baggerly,
director of Grassroots Health, the average adult dose required
to reach healthy vitamin D levels is around 8,000 IUs of vitamin
D per day. For children, many experts agree they need about 35
IUs of vitamin D per pound of body weight. Here, it’s important
to remember that if you’re taking high-dose vitamin D
supplements, you ALSO need to take
vitamin K2, and monitor your levels via blood testing to
ensure that they’re within the optimal range.
More Red Flags for Universal Flu Vaccination
Recent research on pigs, using whole, killed flu viruses,
raises very important questions about the approach taken in the
development of a universal flu vaccine. The study in piglets
found that getting vaccinated against one strain of influenza
raised the risk of severe infection with a related but
different influenza strain.11The researchers refer to this effect as
“vaccine-associated enhanced respiratory disease.” Wisely
enough, they recommend their findings “should be considered
during the development and assessment of experimental universal
flu vaccines.”
Specifically, while the featured study is centered on a
universal flu vaccine that would work by enhancing your immune
system’s production of CD8 T cells, others are trying to create
such vaccines by trying to boost vaccine-acquired immunity by
targeting “stalk antibodies.”
Researchers have learned that the stem or stalk of the main
protein of the flu virus, called hemagglutinin, tends to remain
fairly unchanged across the various viruses. This is the
discovery that has resulted in the current search for a
“universal” flu vaccine. Vaccine developers believe that by
removing the head portion, namely the stalk—i.e. the dominant
protein portion of the virus—they might be able to induce
cross-reactive antibodies capable of protecting against
virtually any influenza virus, regardless of whether it’s an H1,
H3, or H5, and so on.
The recent flu vaccine research in pigs raises a huge
red flag calling into question the validity of this hypothesis,
however. After giving piglets an H1N2 vaccine, they were then
exposed to the H1N1 virus in circulation during 2009. As
reported:12
“Instead of being protected, the H1N2-vaccinated pigs
developed more severe disease than exposed pigs that hadn’t
been pre-vaccinated. When the researchers tested the blood
of the vaccinated pigs, they found high
levels of antibodies that attached to the stalk of the H1N1
hemagglutinin, but not to the head of the protein.… [the researchers] are still trying to figure
out why this produces more severe disease.
But the theory is that while the stalk
antibodies can’t neutralize or kill invading viruses, they
do bind to them. And that may actually help the viruses
enter the cells and multiply to higher levels—the
paper calls them 'fusion enhancing.'” [Emphasis mine]
So even if a universal influenza vaccine is created, it’s
unknown if it will actually work… or
produce unforeseen consequences like we have seen with flu
vaccines so far. Avoiding a serious case of influenza is not
about vaccination anyway, but more about maintaining a healthy,
well-functioning immune system that will naturally assist you in
staying well during the flu season and all year around. By
following the
simple guidelines outlined in this past article, you can
help keep your immune system in optimal working order so that
you're far less likely to acquire the infection to begin with
or, if you do get sick with the flu, you are better prepared to
move through it without complications and soon return to good
health.
Protect Your Right to Informed Consent and Vaccine Exemptions
With all the uncertainty surrounding the safety and efficacy
of vaccines, it's critical to protect your right to informed
consent to vaccination and fight to protect and expand vaccine
exemptions in state public health laws. The best way to do this
is to get personally involved with your state legislators and
the leaders in your community.
THINK GLOBALLY, ACT LOCALLY.
Mass vaccination policies are made at the federal level but
vaccine laws are made at the state level. It is at the state
level where your action to protect your vaccine choice rights
can have the greatest impact. It is critical for EVERYONE to get
involved now in standing up for the legal right to make vaccine
choices in America because those choices are being threatened by
lobbyists representing drug companies, medical trade
associations and public health officials, who are trying to
persuade legislators to strip all vaccine exemptions from public
health laws.
Signing up for the National Vaccine Information Center’s free
Advocacy Portal at
www.NVICAdvocacy.org gives you immediate, easy access to
your own state legislators on your Smart Phone or computer so
you can make your voice heard. You will be kept up-to-date on
the latest state bills threatening your vaccine choices and get
practical, useful information to help you become an effective
vaccine choice advocate in your own community. Also, when
national vaccine issues come up, you will have the up-to-date
information and call to action items you need at your
fingertips.
Share Your Story with the Media and People You Know
If you or a family member has suffered a serious vaccine
reaction, injury or death, please talk about it. If we don't
share information and experiences with each other, everybody
feels alone and afraid to speak up. Write a letter to the editor
if you have a different perspective on a vaccine story that
appears in your local newspaper. Make a call in to a radio talk
show that is only presenting one side of the vaccine story.
I must be frank with you; you have to be brave because you
might be strongly criticized for daring to talk about the "other
side" of the vaccine story. Be prepared for it and have the
courage to not back down. Only by sharing our perspective and
what we know to be true about vaccination will the public
conversation about vaccination open up so people are not afraid
to talk about it.
We cannot allow the drug companies and medical trade
associations funded by drug companies or public health officials
promoting forced use of a growing list of vaccines to dominate
the conversation about vaccination. The vaccine injured cannot
be swept under the carpet and treated like nothing more than
"statistically acceptable collateral damage" of national
one-size-fits-all mandatory vaccination policies that put way
too many people at risk for injury and death. We should be
treating people like human beings instead of guinea pigs.
Internet Resources Where You Can Learn More
I encourage you to visit the following web pages on the
National Vaccine Information Center (NVIC) website at
www.NVIC.org:
NVIC
Memorial for Vaccine Victims: View
descriptions and photos of children and adults who have
suffered vaccine reactions, injuries and deaths. If you or
your child experiences an adverse vaccine event, please
consider posting and sharing your story here.
Vaccine Freedom Wall: View or post
descriptions of harassment and sanctions by doctors,
employers, school and health officials for making
independent vaccine choices.
Connect with Your Doctor or Find a New One That Will Listen and
Care
If your pediatrician or doctor refuses to provide medical
care to you or your child unless you agree to get vaccines you
don't want, I strongly encourage you to have the courage to
find another doctor. Harassment, intimidation, and refusal
of medical care is becoming the modus operandi of the medical
establishment in an effort to stop the change in attitude of
many parents about vaccinations after they become truly educated
about health and vaccination.
However, there is hope.
At least 15 percent of young doctors recently polled admit
that they're starting to adopt a more individualized approach to
vaccinations in direct response to the vaccine safety concerns
of parents. It is good news that there is a growing number of
smart young doctors, who prefer to work as partners with parents
in making personalized vaccine decisions for children, including
delaying vaccinations or giving children fewer vaccines on the
same day or continuing to provide medical care for those
families, who decline use of one or more vaccines.
So take the time to locate a doctor, who treats you with
compassion and respect and is willing to work with you to do
what is right for your child.