Diabetes Drug May Reverse Alzheimer'sMonday, 16 Sep 2013 05:11 PM
A commonly prescribed diabetes drug may have the potential to
reverse some of the damage caused by Alzheimer's disease in the
later stages of the condition.
In a new study funded by the Alzheimer's Society and published in
the journal Neuropharmacology, Lancaster University
researchers found the drug liraglutide may reverse memory loss and
the build-up of plaques on the brain linked to the disease. Mice
with late-stage Alzheimer's given the drug performed significantly
better on an object recognition test and their brains showed a 30
percent reduction in the build-up of toxic plaques.
ALERT: 5 Signs You’ll Get Alzheimer’s Disease Liraglutide — one of new class of drugs known as GLP-1 analogues — is used to stimulate insulin production in diabetes, but research shows it can also pass through the blood brain barrier and have a protective effect on brain cells.
The findings come as the Alzheimer's Society charity prepares to
conduct clinical trials of the drug's effectiveness, as part of a
program that aims to repurpose existing drugs as dementia treatments
within the next five to 10 years.
"Developing new drugs from scratch can take 20 years and hundreds of
millions of pounds," said Doug Brown, M.D., research and development
director at the Alzheimer's Society. "We owe it to [dementia
paitients] to do everything we can to accelerate the process. Our
focus on repurposing existing drugs as dementia treatments is an
incredibly exciting way of bringing new treatments closer.
"This exciting study suggests that one of these drugs can reverse
the biological causes of Alzheimer's even in the late stages and
demonstrates we're on the right track. We're now funding a major new
trial to bring it closer to a position where it can be improving the
lives of people with dementia."
Alzheimer's disease, the most common form of dementia, has few
effective treatments and no cure. If successful in clinical trials
liraglutide would be the first new dementia treatment in a decade.
ALERT: 5 Signs You’ll Get Alzheimer’s Disease © 2013 NewsmaxHealth. All rights reserved. http://www.newsmaxhealth.com/Health-News/diabetes-drug-reverses-alzheimer/2013/09/16/id/525999 |