New Studies Show Optimizing Vitamin D Levels May Double Chances of
Surviving Breast Cancer
Lower LDL Cholesterol, and Helps Prevent Autism
April 13, 2014
Story at-a-glance
A recent meta-analysis found that breast cancer patients
who had high vitamin D levels (average 30 ng/ml) were
twice as likely to survive compared to women with low
levels (average 17 ng/ml)
Vitamin D has a number of anticancer effects, including
the promotion of cancer cell death, and the inhibition
of angiogenesis (the growth of blood vessels that feed a
tumor)
Previous research has shown that a vitamin D level of 50
ng/ml is associated with a 50 percent lower risk of
breast cancer
Recent research found that vitamin D in combination with
calcium appears to reduce LDL cholesterol levels in
postmenopausal women
Vitamin D deficiency may cause autistic behavior through
its effects on the brain hormones serotonin, oxytocin,
and vasopressin, all of which are associated with social
behavior
By Dr. Mercola
For many of you, the hint of spring is on the horizon and the
opportunity to finally expose your skin to healthy doses of sunshine
is very close. Remember that this is a far better choice than using
oral vitamin D, as that is how your body was designed to get healthy
vitamin D levels.
There are many reasons to be conscious of vitamin D, but today's
featured study will focus on breast health. A robust and rapidly
growing body of research clearly shows that vitamin D is
absolutely critical for good health and disease prevention, in
part due to the fact that it influences about 10 percent of all your
genes.
Just one example of an important gene that vitamin D up-regulates
is your ability to fight infections and chronic inflammation. It
also produces over 200 anti-microbial peptides, the most important
of which is cathelicidin, a naturally occurring broad-spectrum
antibiotic.
Recent studies demonstrate how optimizing your vitamin D levels
may lower your LDL cholesterol levels and double your chances of
surviving breast cancer. Researchers also claim to have discovered a
causal link between vitamin D deficiency and autism spectrum
disorder.
Vitamin D for Breast Cancer
Since the early 2000s, scientific investigations into the effects
of vitamin D have ballooned. By the end of 2012, there were nearly
34,000 published studies on the effects of vitamin D, and there are
well over 800 references in the medical literature showing
vitamin D's effectiveness against cancer alone.
According to Carole Baggerly, founder of
GrassrootsHealth, as
much as 90 percent of ordinary breast cancer may in fact be related
to vitamin D deficiency.
Most recently, a meta-analysis of five studies published in the
March 2014 issue of Anticancer Research1
found that patients diagnosed with breast cancer who had high
vitamin D levels were twice as likely to survive compared to women
with low levels.2,
3,
4
The analysis included more than 4,500 breast cancer patients over
a nine-year period. The high serum group had an average vitamin D
level of 30 nanograms per milliliter (ng/ml). Women in the low serum
group averaged 17 ng/ml, which is the average vitamin D level found
in American breast cancer patients.5
The study was co-authored by Professor Cedric F. Garland—featured
in the 2011 video above—along with other researchers at the San
Diego School of Medicine. Funding for the research6
was in part provided by a Congressional allocation to the Penn State
Cancer Institute of the Milton S. Hershey Medical Center.
Vitamin D has a number of anticancer effects, including the
promotion of cancer cell death, known as apoptosis, and the
inhibition of
angiogenesis (the growth of blood vessels that feed a tumor).
According to Dr. Garland:
"As long as vitamin D receptors were present, tumor
growth was prevented and kept from expanding its blood supply.
Vitamin D receptors are not lost until a tumor is very advanced.
This is the reason for better survival in patients whose vitamin
D blood levels are high."
The researchers urge physicians to make vitamin D monitoring and
optimization part of standard breast cancer care, and recommend that
breast cancer patients should restore their vitamin D levels to a
normal range of 30-80 ng/ml. According to the featured findings, you
need at least 30 ng/ml of serum 25-hydroxyvitamin D
(25(OH)D) to prevent cancer from spreading. That said, other
research suggests you'd be better off with levels as high as 80
ng/ml.
How Much Vitamin D Is Required for Breast Cancer Prevention?
In 2011, Dr. Garland's team found that a vitamin D level of 50
ng/ml is associated with a 50 percent lower risk of breast cancer.7,
8 (Similarly, a 2007 study published in the American
Journal of Preventive Medicine9
concluded that a vitamin D level of more than 33 ng/mL was
associated with a 50 percent lower risk of colorectal cancer.)
In the featured video above, GrassrootsHealth founder Carole
Baggerly interviews Dr. Garland about those 2011 findings.
At that time, they discovered that in order to achieve protective
levels, you have to take far more supplemental vitamin D than
previously thought. To reach a minimum protective level of 40 ng/ml
of vitamin D, study participants had to take anywhere from 1,000 IUs
to as much as 8,000 IUs of vitamin D3 per day—a far cry from the
recommended daily allowance of 600 IUs of vitamin D for adults.
The supplemental dose ensuring that 97.5 percent of the study
population achieved a serum 25(OH)D of at least 40 ng/mL was 9,600
IU/day. This study also concluded that intake of up to 40,000 IUs
per day is unlikely to result in vitamin D toxicity.
It's important to note, however, that it's virtually impossible
to make a general recommendation on how much vitamin D to take as
the amount needed can vary significantly from one
individual to another. In essence, you need to regularly monitor
your levels, and take whatever amount of vitamin D3 you need to
maintain a clinically relevant level.
In related news, a recently published study10
found that vitamin D in combination with calcium appears to reduce
LDL cholesterol levels in postmenopausal women. As reported by the
New York Times:11
"Researchers randomly assigned 576 postmenopausal women
to either a daily dose of 400 units of vitamin D and 1,000
milligrams of calcium, or a placebo. They followed them for
three years. By the end of the study, published in
Menopause,12
the vitamin D group had significantly higher serum levels of
vitamin D, and a small but notable drop in LDL."
Women taking a combination of vitamin D and calcium had a 4.46
mg/dL mean decrease in LDL cholesterol. Previous
research by Dr. Stephanie Seneff also suggests that healthy
cholesterol and sulfur levels are highly dependent on your
vitamin D levels. Through her research, she believes that the
mechanism we call "cardiovascular disease," of which arterial plaque
is a hallmark, is actually your body's way to compensate for not
having enough cholesterol sulfate.
Sun Exposure Is Likely the IDEAL Way to Optimize Your Vitamin D
Levels
To summarize Dr. Seneff's findings, high LDL appears to be a sign
of cholesterol sulfate deficiency. According to Dr. Seneff, your
body's way of trying to maintain the correct balance is to take
damaged LDL and turn it into plaque. Within this plaque, your blood
platelets produce cholesterol sulfate, which your heart and brain
needs for optimal function.
Her research also suggests that in order to truly optimize your
cholesterol levels, you really need to get your vitamin D from sun
exposure, and here's why: when you expose your skin to sunshine,
your skin synthesizes vitamin D3 sulfate. This form of vitamin D is
water-soluble, unlike oral vitamin D3 supplements, which is
unsulfated. The water-soluble form can travel freely in your blood
stream, whereas the unsulfated form needs LDL (the so-called "bad"
cholesterol) as a vehicle of transport. Dr. Seneff suspects that the
simple oral non-sulfated form of vitamin D likely will not provide
the same benefits as the vitamin D created in your skin from sun
exposure, as it cannot be converted to vitamin D sulfate.
If you're still under the mistaken impression that sun exposure
is the primary cause of skin cancer, the following explanation may
be of great help. Dr. Seneff states that:
"Both cholesterol and sulfur afford protection in the
skin from radiation damage to the cell's DNA, the kind of damage
that can lead to skin cancer. Cholesterol and sulfur become
oxidized upon exposure to the high frequency rays in sunlight,
thus acting as antioxidants to 'take the heat,' so to speak.
Oxidation of cholesterol is the first step in the process by
which cholesterol transforms itself into vitamin D3."
Additionally, distorted omega-3 to omega-6 ratios play a major
role in the development of skin cancers too. In 2001, the National
Academy of Sciences published a comprehensive review13
showing that the omega 6:3 ratio was the key to preventing skin
cancer development. An Australian study14
published in 1993 showed a 40 percent reduction in melanoma for
those who were eating fish, which is rich in omega-3s. And this was
without any attention to lowering omega-6 fats. Omega-3 and omega-6
fats are both essential for human health. However, the typical
American consumes far too many omega-6 fats in their diet while
consuming very low levels of omega-3. While the ideal ratio of
omega-6 to omega-3 fats is 1:1, our ratio of omega-6 to omega-3
averages from 20:1 to 50:1.
Evidence of Causal Link Between Vitamin D, Serotonin Synthesis, and
Autism Emerges
Vitamin D may also be critical in the fight against autism
spectrum disorder (ASD). According to a study15,
16 by the Children's Hospital Oakland Research Institute,
vitamin D may affect autistic behavior by activating a gene
responsible for the production of tryptophan hydroxylase 2 (TPH2),
an enzyme that converts tryptophan to serotonin in your brain. The
research also shows that two other brain hormones associated with
social behavior, oxytocin and vasopressin, are activated by vitamin
D. As reported by Newswise:17
"This suggests that adequate levels of vitamin D may be
required to produce serotonin in the brain where it shapes the
structure and wiring of the brain, acts as a neurotransmitter,
and affects social behavior. They also found evidence that the
gene that makes the enzyme tryptophan hydroxylase 1 (TPH1) is
inhibited by vitamin D hormone, which subsequently halts the
production of serotonin in the gut and other tissues, where when
found in excess it promotes inflammation.
This mechanism explains many of the known, but previously
not understood, facts about autism including: 1) the 'serotonin
anomaly' low levels of serotonin in the brain and high levels in
the blood of autistic children; 2) the preponderance of male
over female autistic children: estrogen, a similar steroid
hormone, can also boost the brain levels of serotonin in girls;
3) the presence of autoimmune antibodies to the fetal brain in
the mothers of autistic children: vitamin D regulates the
production of regulatory T-cells via repression of TPH1"
The researchers propose treating ASD with a combination of
vitamin D, tryptophan, and omega-3 fats in order to naturally
elevate the concentration of brain serotonin without side effects.
This isn't the first time vitamin D has been implicated as a
contributing factor to rising autism rates. According to previous
research,18
there is indeed a link between rampant vitamin D deficiency in
pregnant women and the proportionate jump in autism. The reason for
this is because vitamin D receptors appear in a wide variety of
brain tissue early in the fetal development, and activated vitamin D
receptors increase nerve growth in your brain.
It is my personal belief that this may be one of the largest
contributing factors to autism and that it is a deficiency of sun
exposure to the pregnant mom, and subsequently to the fetus, that
puts the child at a massively increased risk for abnormal brain
development. I believe one of the most important changes that could
radically reduce autism is to make sure ALL pregnant women have
their vitamin D levels normalized to 50-70 ng/ml.
Have You Tested Your Vitamin D Level Yet?
Right now, after several months of winter and minimal sun
exposure, is an ideal time to test your vitamin D levels to get an
idea of what your levels are at their lowest. If you're low, take
proactive measures to raise your levels, and then retest in
mid-summer.
The
D*Action Project by GrassrootsHealth is a very cost effective
solution. To participate, simply purchase the D*Action Measurement
Kit and follow the registration instructions included. (Please note
that 100 percent of the proceeds from the kits go to fund the
research project. I do not charge a single dime as a distributor of
the test kits.)
As a participant, you agree to test your vitamin D levels twice a
year during a five-year study, and share your health status to
demonstrate the public health impact of this nutrient. There is a
$65 fee every six months for your sponsorship of this research
project, which includes a test kit to be used at home,
and electronic reports on your ongoing progress. You will get a
follow up email every six months reminding you "it's time for your
next test and health survey."
As for HOW to optimize your vitamin D levels, I firmly believe
that appropriate sun exposure is the best way. In fact, I personally
have not taken a vitamin D supplement for three or four years, yet
my levels are in the 70 ng/ml range. There's a handy smartphone app
called DMinder (dminder.info)
that will tell you how much UV radiation you're getting and how many
IUs of vitamin D you're making based on your local weather
conditions (reported from the weather service) and other individual
parameters such as your skin tone and age. It will also tell you
when to get out of the sun, to protect yourself from
sunburn.
If you can't get enough sunshine, then a safe tanning bed would
be your next best option. Most tanning equipment use magnetic
ballasts to generate light. These magnetic ballasts are well known
sources of
EMF
fields that can contribute to cancer. If you hear a loud buzzing
noise while in a tanning bed, it has a magnetic ballast system. I
strongly recommend you avoid these types of beds and
restrict your use of tanning beds to those that use electronic
ballasts.
If your circumstances don't allow you to access the sun or a safe
tanning bed, then you really only have one option if you want to
raise your vitamin D, and that is to take a vitamin D supplement.
GrassrootsHealth has
a helpful chart showing the average adult dose required to reach
healthy vitamin D levels based upon your measured starting point.
Many experts agree that 35 IUs of vitamin D per pound of body weight
could be used as an estimate for your ideal dose.
If You Opt for Oral Vitamin D, Remember Vitamin K2
Last but not least, if you do opt for a vitamin D supplement, you also
need to take
vitamin K2. The biological role of vitamin K2 is to help move
calcium into the proper areas in your body, such as your bones and
teeth. It also helps remove calcium from areas where it shouldn't be,
such as in your arteries and soft tissues.
Vitamin K2 deficiency is actually what produces the consequences
similar to vitamin D toxicity, which includes inappropriate
calcification that can lead to hardening of your arteries. The reason
for this is because when you take vitamin D, your body creates more
vitamin K2-dependent proteins that move calcium around in your body.
Without vitamin K2, those proteins remain inactivated, so the benefits
of those proteins remain unrealized. So remember, if you take
supplemental vitamin D, you're creating an increased demand for K2.
Together, these two nutrients help strengthen your bones and improve
your heart health.
Copyright 1997- 2014 Dr. Joseph Mercola. All Rights Reserved.