The Whole Toxic Enchilada

Last week, while we waited for the U.S. Environmental Protection Agency (EPA) to announce whether or not the agency will give Monsanto’s Roundup a free pass by green lighting the use of glyphosate for another 15 years, the EPA’s counterpart in the EU made its own big announcement.

Glyphosate is “unlikely to cause cancer” said the authors of the new report by the European Union Food Safety Authority (EFSA).

That headline, music to Monsanto’s ears, seemed to fly in the face of the findings published earlier this year by the World Health Organization (WHO). After extensive review of the evidence, all 17 of WHO’s leading cancer experts said glyphosate is a “probable human carcinogen.”

Sustainable Pulse (SP), publisher of global news on GMOs and other food-related issues, quickly reported the glaring omission made by the majority of news sources reporting on EFSA’s findings. 

According to SP, what EFSA really concluded is this: Glyphosate by itself doesn’t cause cancer (a fact other scientists dispute). But products like Monsanto’s Roundup, which contain glyphosate and other additives and chemicals that are essential to making the herbicide work? That’s another, or in this case, the rest of the story.

According to the EFSA report: 

It is likely, therefore, that the genotoxic effects observed in some glyphosate-based formulations are related to the other constituents or “co-formulants.”

Bingo. Take some glyphosate, mix it up with other chemicals, and you’ve got yourself a cancer-causing concoction. (Genotoxic means “damaging to DNA and thereby capable of causing mutations or cancer). Remove those additives (or adjuvants as scientists refer to them), and you’ve got yourself a weed killer that doesn’t work. From SP: 

Independent scientists have long warned that pesticides are authorized for use based on medium- or long-term tests on laboratory animals carried out with a single chemical ingredient, which is known as the active ingredient because it is assumed to be responsible for giving the pesticide its pest- or weedkilling action.

However, the complete pesticide formulations as sold and used also contain additives (adjuvants), which increase the pest- or weedkilling activity of the pesticide. These complete formulations do not have to be tested in medium- and long-term tests – even though they are the substances to which farmers and citizens are exposed.

That would explain the difference between EFSA’s conclusion, based on its assessment of glyphosate alone, and the WHO findings, based on studies of glyphosate in combination with the other additives .

EFSA’s statement, and strong warning to EU member states that they might want to take a closer look at the whole toxic enchilada before they draw their own conclusions about glyphosate and Roundup, was anything but music to Monsanto’s ears. Because EFSA’s findings could, and should, change the way agencies like the EPA and EFSA study the toxic effects of herbicides.

We checked in with André Leu, author of the “Myths of Safe Pesticides,” for his take on the EFSA report. 

“No surprise,” said Leu, who told us he’s devoting a whole chapter in his new book to how the pesticide industry has corrupted EFSA and the EPA. “I’ll reveal the background on how Monsanto's ‘Glyphosate Task Force' wrote the EFSA glyphosate reassessment report almost word for word to justify lifting the residue limits.”

According to Leu, both glyphosate alone, and formulations like Roundup, are genotoxic. He said research has shown that glyphosate “can cause genetic damage, developmental disruption, morbidity, and mortality even at what are currently considered normal levels of use.”

Leu cited a study published in 2004, which found that glyphosate-based herbicides caused cell-cycle dysregulation, which leads to cancers. Researchers involved in that study said: “Cell-cycle dysregulation is a hallmark of tumor cells and human cancers. Failure in the cell-cycle checkpoints leads to genomic instability and subsequent development of cancers from the initial affected cell.” The researchers behind the 20014 study tested several glyphosate-based pesticides and found that all of them caused cell-cycle dysregulation.

Leu also referred to the article “Differential Effects of Glyphosate and Roundup on Human Placental Cells and Aromatase,” published in 2005  in Environmental Health Perspectives. The article revealed evidence that glyphosate damaged human placental cells within 18 hours of exposure, even at concentrations lower than those found in commercially available pesticides and herbicides. According to the scientists who conducted the study “this effect increases with concentration and time or in the presence of Roundup adjuvants.”

And then there’s the study published in the journal Toxicology.  Scientists studied four different commercial glyphosate formulations and observed breaks in 50 percent of the DNA strands in human liver cells at doses as low as five parts per million. This damage affects the way DNA sends messages to several physiological systems, including the endocrine system. According to the study’s authors, Leu said, this is significant because the liver is the first detoxification organ and is sensitive to dietary pollutants.

“The good news is that this may be the beginning of testing pesticide formulations for chronic and non-contagious diseases,” Leu said. “Currently some pesticide formulations are tested for acute toxicity—the amount that will kill you in two weeks—but not for all the long-term diseases like cancer, endocrine, nervous, immune metabolic, birth defects, and on and on. Not one of the thousands of formulations that are used on our food are tested for these longer term diseases.”

We’ve heard from EFSA. Now it’s time to hear from the EPA, an agency known for not heeding the warnings of its own scientists, at least not when Monsanto’s profits hang in the balance.

Please ask the EPA to ban glyphosate and Monsanto’s Roundup. Once and for all.

Katherine Paul is associate director of the Organic Consumers Association. 

https://www.organicconsumers.org/blog/monsanto%E2%80%99s-roundup-whole-toxic-enchilada