Healing the Body With Photobiomodulation
February 26, 2017
Story at-a-glance
By Dr. Mercola Photobiomodulation therapy has important implications for health that many are still under-informed about. In this interview, photodynamic therapy researcher Michael Hamblin, Ph.D., who is an expert in this area, sets out to improve our understanding of this important field. Hamblin is a researcher and associate professor of dermatology at Harvard Medical School. He’s also a principal investigator at The Wellman Center for Photomedicine at Massachusetts General Hospital, and a member of the Harvard-MIT Division of Health Sciences and Technology. Infrared therapy is one aspect of photobiomodulation, which covers light of all wavelengths — visible light, and light from spectral regions including ultraviolet, blues through the green, red and into the near-, mid- and far-infrared wavelengths. One of the most commonly used wavelengths of light is the near-infrared, which starts at about 750 nanometers (nm) and goes all the way into 1,200 nm. Near-infrared in the lower range penetrates well into the body and has many beneficial biological effects. Wavelengths beyond 1200 nm have very limited ability to penetrate deeply into the body. Another type of infrared radiation commonly used is far-infrared, which also has biological effects. That’s the type of infrared you get from an infrared heat lamp or far-infrared sauna. More specifically, an infrared heat lamp will give off mostly far-infrared; about 10 percent of the energy is near-infrared. Far-Infrared Light Affects Your Biology by Altering the Properties of Structured WaterThe two principal biological chromophores (light-absorbing chemicals) in photobiomodulation are the mitochondrial enzyme called cytochrome c oxidase (COO) and simple water. Far-infrared is absorbed by water, which is why it cannot penetrate as deeply as the lower near-infrared range. The higher near-infrared wavelengths are also absorbed by water. Now, if light energy is absorbed by the water in your body, how does the light affect your biology? Hamblin explains:
Biological Effects of Near-InfraredThe mechanism of action for far-infrared differs from the red and near-infrared, the latter of which primarily targets the COO in the mitochondria. The accepted mechanism in the mitochondria involves dissociation of the inhibitory molecule called nitric oxide (NO) from COO, increasing electron transport and ATP synthesis. NO also has important signaling effects.
Near-Infrared Helps Fuel Your BodyYou probably know that the food you eat is converted to generate ATP. But the mechanism of ATP production can also be stimulated in response to near-infrared exposure, which triggers the mitochondria to produce additional ATP. So, it could be said that your body is fueled by both food and sunlight. More specifically, light allows your body to use food more efficiently. In other words, light helps the cells make the best use of whatever food they have, and improves the generation of energy. “For instance, light seems to combine very well with modest amounts of exercise,” Hamblin says. The ideal way to receive most of this exposure would be to simply go outside, exposing as much skin as possible. Unfortunately, there are many areas where this would be impractical in the winter. This is where therapeutic light devices can be helpful. The optimal wavelength for stimulating COO lies in two regions, red at 630 to 660 nm and near-infrared at 810 to 830 nm. Multiple studies have also failed to detect a difference between red light (660 nm) and near-infrared (810, 830). So, the mid-600s and all of the wavelengths in the low 800s appear to have the same biological impact. What this means is that the red light at 630-660 nm will provide the same mitochondrial benefits as the near-infrared range of 810 to 830 nm. Curiously enough, 730 nm does virtually nothing. One theory is that the absorption spectrum of COO has two peaks: one in the mid-600s and one at around 800. Ideal Power DensityIt’s important to realize that photobiomodulation is highly biphasic in dose, meaning the benefit can disappear by using too much light. There’s a dose range in which it will give you benefit. Below that there is no effect and if you go a lot above the optimum you can actually cause harm. One factor to take into consideration is the power density, measured in milliwatts per square centimeter. There’s a 10- and 20-fold positive window. This means you could give 2 milliwatts per square centimeter or 30 milliwatts per square centimeter, and both would be effective. However, if you went to several hundred milliwatts it could be harmful. As a general rule, an ideal power density is around 10 milliwatts per square centimeter. Most photobiomodulation devices use between 10 and 20 milliwatts per square centimeter. Get the Right DoseThe second factor is the dose, which is typically calculated in joules per square centimeter. Hamblin explains:
Frequency ModulationThe third factor is the frequency. Most of the devices referenced here are continuous wave, not pulsed, so there is no frequency. There’s just a steady stream of photons coming out. You can modulate by pulsing the light, however. An ideal frequency is between 10 and 40 hertz. Anything over 100 hertz is unlikely to have a biological effect, or may even have a negative biological effect.
Sunbathing Versus HeliotherapyHeliotherapy clinics were all the rage in Europe some 100 years ago. Patients would visit clinics in the Alps where they’d bask in the sun to treat a wide variety of chronic health conditions. Oscar Bernhardt, an early pioneer in this field, stressed the importance of sun exposure in mountainous areas.
But why is sunlight so much better up in the mountains? Hamblin believes it has to do with the fact that, at high altitudes, there’s much less atmosphere, and the lower oxygen level makes your mitochondria work at a different rate. The oxidative phosphorylation is more skewed toward glycolysis because the oxygen availability is lower.
What Can Photobiomodulation Treat?Most of the original research on photobiomodulation was done with lasers, but now they’ve started using light emitting diodes (LEDs), which are more cost-effective and don’t have any safety concerns. LEDs also seem to be a more effective and efficient way to administer the therapy. A recent trend is flexible, wearable LED arrays that you can wrap around your joints or put on your head or back — typically to treat pain or degenerative conditions. They even have organic LEDs (OLEDs), where the actual light emitting substance is flexible. Different wavelengths impart different benefits: • Blue wavelengths seem to be particularly good for relieving pain. On the other hand, extended exposure can damage the retina. As noted by Hamblin:
• Red light is good for relieving inflammation and inflammatory conditions. Interestingly, the literature is rife with reports on improving macular degeneration (the most common cause of blindness in the U.S.) with exposure to red light at 660 nm. • Near-infrared is good for regeneration of deeper structures such as tendons, bones and cartilage; orthopedic and musculoskeletal problems. Red or near-infrared light at night also produces melatonin and helps you sleep. Near-infrared may also be useful for kidney problems. Anecdotal evidence suggests it could be a powerful therapy for kidney failure.
Folks, this is a GOLDEN pearl from this interview. Who would have ever thought that shining a light over your kidneys could radically improve kidney disease? It’s certainly something that needs to be seriously considered by those with kidney impairment, as there is virtually no down side. Additionally, I have reviewed studies showing shining the light over your thyroid gland can be useful for autoimmune thyroiditis. Near-Infrared Also Benefits Eyes, Diabetes and Athletic PerformanceMetabolic syndrome and diabetes are two other conditions that could benefit from near-infrared light exposure. According to Hamblin, most people will place the light on the belly, as it is anti-inflammatory and can have a beneficial effect on fat deposits. Near-infrared (810 to 830 nm) is also good for your eyes, so there’s little risk in facing the light. Red light at 630 nm can dazzle you and take a while to recover from, but it’s not actually harmful to your eyes. The startup company LumiThera is presently suggesting treating age-related macular degeneration with a photobiomodulation device that shines red and near-infrared light into your eyes.
Light Therapy May Boost Cognitive FunctionAnother fascinating area of discovery is the use of light to improve brain function. I recently interviewed Dr. Lew Lim about infrared light therapy for Alzheimer’s disease. I will be publishing that interview shortly, so be sure to keep an eye out for it. It’s fascinating stuff. Photons can be absorbed by the blood flowing in the skin, and it’s known that light is very good at activating stem cells in bone marrow.
Photobiomodulation — Medicine of the Future, TodayPhotobiomodulation has been around for centuries but it’s only in the last 50 years that its mechanisms have become (at least partly) understood. Unfortunately, as the pharmacological paradigm grew, so did the emphasis on expensive and dangerous medications. As a result, many simple yet profoundly effective and inexpensive strategies fell by the wayside. Take psychiatric drugs for example. They have virtually no positive benefits, but a large number of very serious side effects. For brain health and Alzheimer’s, “just putting a simple near-infrared light on your head works better than these drugs,” Hamblin says. I sincerely hope that interest in these kinds of modalities will grow, and that scientists and medical professionals will give it more attention. As a layperson, you could also follow the parameters given to safely and successfully integrate this kind of light therapy into your life at a relatively low cost. © Copyright 1997-2017 Dr. Joseph Mercola. All Rights Reserved. http://articles.mercola.com/sites/articles/archive/2017/02/26/photobiomodulation.aspx |